Anti-Heal
Items and effects that reduce a target's healing, shield, and regen effectiveness.
Anti-heal (also called anti-regen) reduces how much HP a target recovers from lifesteal, spell vamp, shields, and regeneration — Sea Halberd's Lifebane passive cuts this to roughly 60% effectiveness on physical builds, while Necklace of Durance does the same for magic builds. It's built reactively, as soon as an enemy sustain hero or lifesteal-heavy build becomes a problem, typically by item 2 or 3. Against a team with a dedicated healer like Estes or Floryn, anti-heal itemization is often mandatory rather than optional.